<!-- Preferences start here * Set PAGETITLE = Barrick Lab :: UT Austin Preferences end here --> ---+ Barrick Lab :: Home <table width'"100%"><tr><td><div style="float: right; margin:10px;"><a href="%WIKIHOMEURL%/%WEB%/FormerFrontPageImages"><img style="border-color: black; border-style: solid; border-width: 3px;" width=270 height=270 src="%PUBURL%/%WEB%/FrontPageImages/Grid_Plate_Small.png"></a><br><div align=center><b>Tangled universe of microbial evolution<br>[[http://cafepress.com/barricklab][«Support the Barrick lab coffee fund»]]</b></div></div><div style="text-align:justify"> <table bgcolor="CCFFCC" style="min-width:400px;text-align:left"><tr><td> <img src="%PUBURL%/%WEB%/WebLeftBar/CPRIT_icon.png"> *December 2012:* The Cancer Prevention & Research Institute of Texas ([[http://www.cprit.state.tx.us/][CPRIT]]) funds research in the Barrick lab to study "Deep sequencing oncoviral evolvomes as a personalized cancer diagnostic tool".</td></tr></table> <table bgcolor="DED29E" style="min-width:400px;text-align:left"><tr><td> <img src="%PUBURL%/%WEB%/WebLeftBar/iGEM.png"> *November 2012:* UT Austin iGEM team wins *Best Measurement* award at regional competition and advances to the world championship for their project involving [[http://2012.igem.org/Team:Austin_Texas/Caffeinated_coli][addicting <i>E. coli</i> to caffeine]]. They make a case for updating assembly standards for Gibson assembly amid [[http://ellingtonlab.org/blog/2012/11/09/on-apologetics/][some controversy]] about their refactored decaffeination operon not being accepted as a [[http://partsregistry.org/Help:An_Introduction_to_BioBricks][BioBrick]].</td></tr></table> <table bgcolor="FFCCCC" style="min-width:400px;text-align:left"><tr><td> %ICON{puzzle}% *October 2012:* A postdoctoral researcher position is available in the Barrick lab for projects that combine deep sequencing with synthetic biology and experimental evolution or in vitro selection. [[https://utdirect.utexas.edu/apps/hr/jobs/nlogon/121003010712][View Job Posting (121003010712)]] *Update: This position has been filled.* </td></tr></table> <table bgcolor="FFFFCC" style="min-width:400px;text-align:left"><tr><td> %ICON{choice-yes}% *September 2012:* Our work on the genomics underlying the evolution of a rare metabolic innovation (aerobic citrate utilization) in the Lenski long-term _E. coli_ evolution experiment is published in _Nature_. [[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11514.html][Article]] | [[http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11487.html][News and Views]] | [[http://blogs.discovermagazine.com/loom/2012/09/19/the-birth-of-the-new-the-rewiring-of-the-old/][Carl Zimmer Blog]] </td></tr></table> [[%WIKIHOMEURL%/%WEB%/OldNews][Archived news items »]] We are broadly interested in understanding evolution as a creative force. How does new information about the environment become fixed in genomes over evolutionary time? How do different kinds of mutations affect the ability to further adapt? What limits the speed of adaptation in a given population? What does the organization of information in a genome tell us about its past? Can we map fitness landscapes and chart what evolutionary trajectories are likely to be realized? How are microbial genomes evolving in the wild? Can we harness evolutionary processes to generate organisms or molecules that do useful tasks? Can we anticipate and frustrate the unfortunate evolution of microbial pathogens and cancers? Can we predict what mutations will sabotage the ingenious man-made contraptions of synthetic biology? Answering these questions requires a systems level knowledge that spans the disciplines of evolutionary biology, microbiology, molecular biology, biochemistry, and computer science. Our approach is to use several model systems that allow one to manipulate the evolutionary process and follow the dynamics of evolution in real time: (1) experiments with digital organisms (Avida), (2) in vitro selection and evolution experiments with functional nucleic acids (DNA and RNA), and (3) experiments with bacteria (_E. coli_). There is an element of chance in evolution, and these systems allow one to compare many replicate experiments to quantitatively understand the diversity of possible outcomes. They also allow perfect control of the environment, so that the influences of various factors on evolutionary paths and the biochemical roles of individual mutations can be unambiguously teased apart. Currently, we are reconstructing the fine-scale dynamics of mutations within _E. coli_ populations from a 20-year evolution experiment using next-generation DNA sequencing and high-throughput genotyping methods, modeling these dynamics to understand the evolutionary forces at work, and searching for examples where bacteria with lower fitness than other contending lineages in the same population eventually prevail because they have greater evolutionary potential. </td></tr></table> <!-- <div style="float: right; margin:10px;"><img style="border-color: green; border-style: solid; border-width: 3px;" height=300 width=300 src="%PUBURL%/%WEB%/FrontPageImages/FMN_Aptamer.png"><br><div align=center><b>Riboswitch 2° Structure Prediction</b></div></div> -->
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Topic revision: r76 - 2012-12-07 - JeffreyBarrick